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    2-Deoxy-D-glucose, glucose analog (CAS 154-17-6) 98% .

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    Deoxy-D-glucose, 2-[1,2-3H(N)] - NET549250UC | PerkinElmer

    2-deoxy-D-glucose, labeled at the 1,2 position with tritium. This glucose analog is readily transported into most cells and cannot be further metabolized, and is commonly used in glucose uptake assays.

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    Description: Storage:This product shall be sealed to preserve. This product is crystallize solid.Soluble in water and ethanol.The α type's melting point is 134~136℃.The β type's melting point is 142~144℃.Used in biochemical study.

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    These enantiomerically pure intermediates form useful intermediates for the synthesis of polyols. 2-Deoxy-D-ribose has even been used in a short and efficient synthesis of the enantiomer, 2-deoxy-L-ribose, in a sequence which complements previously reported routes such as the eight-step synthesis from L-ascorbic acid.

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    1 Citation for 2-Deoxy-D-glucose. Citations are publications that use Tocris products. Selected citations for 2-Deoxy-D-glucose include: Lin et al (2017) Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop.

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    2-Deoxy-D-glucose (2-Deoxy-D-arabino-hexose) | Hexokinase .

    The effect of 2-DG on cell growth is determined by evaluating the number of adherent cells. Briefly, MCF-7 cells are plated at 3×10 4 cells per well in flat-bottomed 96-well plates in 100 μL of culture medium under the culture conditions. After 24 hours, cells are fed with fresh medium including 2-Deoxy-D-glucose at doses of 0, 4, 8, or 16 mM.

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    2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.

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    2-Deoxy-D-glucose, glucose analog (CAS 154-17-6) 98% .

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    2-DeoxyGlucose (2-DG) - Blog: Cancer Treatments - from .

    Oct 24, 2015· 2DG differs from normal glucose only by removal of an oxygen atom from the hydroxyl group at the 2 position . When provided exogenously, 2DG is taken up by glucose transporters and is subsequently converted to 2-deoxy-D-glucose 6-phosphate (2DG-6P), which cannot be converted to fructose-6-phosphate by phosphoglucose isomerase.

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    2-Deoxy-D-Glucose. 2-Deoxyglucose is the most commonly used glycolytic inhibitor in plate-based experiments, and in some contexts its use can be difficult to interpret. . The 2-deoxy-glucose technique was used to identify sites of functional abnormality in the dt rat.

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    Use Of 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is used is a natural anti-metabolite antibiotic with a variety of physiological and pharmacological effects such as inhibiting infection, yeast fermentation, pathogenic bacteria and growth of tumor cells.It has anti-bacterial, anti-cancer, anti-epilepsy and other functions, and is used to prevent .

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    These enantiomerically pure intermediates form useful intermediates for the synthesis of polyols. 2-Deoxy-D-ribose has even been used in a short and efficient synthesis of the enantiomer, 2-deoxy-L-ribose, in a sequence which complements previously reported routes such as the eight-step synthesis from L-ascorbic acid.

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    2-deoxyglucose is predominantly used as a diagnostic agent in its radiolabelled form (fluorine-18 is used as the radiolabel).By using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose metabolism, which is altered in diseases such as cardiovascular disease, tumors, and Alzheimer's disease. Therapeutically, 2-deoxyglucose is an investigational drug that is .

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    2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.

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    The wonders of 2-deoxy-d-glucose. Authors. Haibin Xi, Department of Microbiology, Immunology and Molecular Genetics, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA; Search for more papers by this author.

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    4. Anti - Herpes - and treatment of aids We are the largest supplier of 2 deoxy d glucose in the world. 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.

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    2-Deoxy-D-glucose (154-17-6) is a synthetic glucose analog with extensive biological effects. It is commonly thought of as an inhibitor of glycolysis, but its metabolic effects are wide-ranging. 2-Deoxy-D-glucose competitively inhibits glucose uptake via its metabolite 2-Deoxy-D-glucose-6-phosphate, which inhibits hexokinase and phosphoglucose-isomerase leading to decreased ATP production .

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    2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 …

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    Description 2-deoxy-D-Glucose is a non-metabolizable glucose analog that inhibits phosphorylation of glucose by hexokinase, the first step of glycolysis.

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    4. Anti - Herpes - and treatment of aids We are the largest supplier of 2 deoxy d glucose in the world. 2-Deoxy-D-glucose is used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.

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    Description: Storage:This product shall be sealed to preserve. This product is crystallize solid.Soluble in water and ethanol.The α type's melting point is 134~136℃.The β type's melting point is 142~144℃.Used in biochemical study.

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